Stem Cells May Ease Angina in Tough Cases
Explain that cardiac injections of hematopoietic stem cells were found to help relieve refractory chest pain in the first randomized U.S. trial of stem cells for chronic angina.Note that the benefit in reduction in angina persisted at one year, along with a substantial boost in exercise capability.
Point out that this was a phase II study and the use of stem cells for angina may still be years away from clinical practice. , since the first pivotal phase III study isn't slated to get under way until later this year.
But the CD34-positive cells used in the study are routinely used during treatment of certain types of cancer, where they are known as hematopoietic stem cells. These cells boost both bone marrow function and blood vessel formation, which presumably cuts down on the cardiac ischemia that causes angina.
Stem cell therapies for the heart remain experimental except in South Korea, which last week became the first in the world to approve clinical use in acute myocardial infarction.
Tempered Excitement
Refractory angina is a growing problem for which stem cells could be a needed new option, Losordo explained in an interview.
"There's a large pool of patients out there who have really exhausted the currently available treatments," he said. "They've had all the bypass surgery they can have, all the angioplasty and stenting that's possible, are taking maximal and optimal medicines, and are still disabled."
But while Losordo called the results exciting, other experts contacted via email by ABC News in collaboration with MedPage Today were more circumspect.
Bernard Gersh, MD, of the Mayo Clinic in Rochester, Minn., called the results interesting but reaffirmed that "stem cell therapy should be strictly investigational other than in the setting of bone marrow transplants."
Jeff Brinker, MD, of Johns Hopkins, cited "cautious optimism" given the relatively small benefits from cardiac stem cell treatment in prior small studies.
"One should keep in mind that exercise improvement and less angina are soft endpoints and that the number of patients is relatively small," he cautioned, "so that this trial would probably not carry much scientific weight but might justify a larger controlled trial."
Steven Nissen, MD, of the Cleveland Clinic, also urged caution in interpreting the results as preliminary.
Aside from limitations as a small, phase II study, it "required highly invasive methods for administration of stem cells, which may be impractical for routine use," Nissen warned.
Chronic Small Vessel Ischemia - News
the right cerebellar hemisphere, mild cerebral volume loss, and mild T2-weighted hyper-intensities within the periventricular and subcortical white matter that was non-specific and thought to be most likely related to small vessel ischemic disease.
These cells boost both bone marrow function and blood vessel formation, which presumably cuts down on the cardiac ischemia that causes angina. Stem cell therapies for the heart remain experimental except in South Korea, which last week became the first
A normal electrocardiogram (ECG) reveals the electrical activity of the heart which could demonstrates the condition of the heart starved with oxygen- the condition is known as ischemia. Tread mill tests also could reveal any moderate degree of
Questions And Answers On Brain Health Supplements Vitamins ...
Concussion – consulting a doctor?
CONCUSSION
I fell and hit my forehead about an year ago at winter. A bump appeared on the impact spot. It was quite big, but, with some help of the ice, it calmed down and disappeared, or so I thought. I never went to consult a doctor, but now I noticed that on the impact spot, a little bump was left, and it looks like it’s a healed skull but also looks like there’s something else, something like a little usual bump, but it’s still there after all this time. I also experienced a ‘light-heading’ in which I was walking as usual and all the sudden some white light’s appear, i feel pressure in my head and i lose my stability a bit…it usually wears off in few seconds ( in about 4-6 ). That, however, started to be rare, and now it almost never happens, but does sometimes. My head sometimes hurts, too. It’s usually not intense, but sometimes is. So, now I’m worried about my brain ‘s health and am even more worried about that hit I received, because now I think that I might’ve had a concussion and I’m worried as hell about that, because, apparently, my brain and my mind’s skills are the only thing a value about myself. So, as I fear that my IQ and my brain could be permanently damaged, I’m thinking about consulting a doctor now, to see if, considering that something in fact DID happen to my brain , anything could be done, anything at all. But here’s the thing, I’m worried that it’s too late for anything now. So please help me by answering this question as soon as possible. Thanks in regards!
- Additional info about a fall and myself -
1. Myself : So it was winter, I was on rode on a hill going up. I suddenly slipped, fell and hit my forehead. I got lightheaded for a few seconds, so I felt disoriented and had to sit. I felt pressure in my head, but all of that was better seconds after ( maybe 20-50 seconds ). I bump appeared on my forehead ( more about that in the original text ) and my lip started bleeding a bit. I went home few minutes after, when I felt good enough. I didn’t vomit nor did I even feel like it later on. I didn’t lose consciousness either. It was Friday, so I didn’t do anything much that day, just like other 3 days, but after then, I was doing physical activities in school again, but I didn’t do much of that after school ( I was 13 then, by the way ) .
Chronic Small Vessel Ischemia - Bookshelf
Neurovascular Neuropsychology
However, chronic exposure to raised blood pressure reduces this ... Thus, small vessel damage may first lead to ischemic demyelina- tion in the deep white ...Brain Hypoxia-Ischemia Research Progress
The pathogenesis of cerebral small vessel disease is still a matter of ... in lacunar infarction while a more chronic and widespread reduction in perfusion ...Targeting inflammation and neurogenesis in an animal model of small-vessel stroke
However, approximately 25% of first human strokes are caused by small vessel ischemia (Lammie et al., 1998; Greenberg, 2006). In Japan, over 50% of ischemic ...Acute Ischemic Stroke, Imaging and Intervention
However, if the carotid occlusion is chronic, the organized clot might extend up from the ... Small-vessel occlusive disease is almost entirely related to ...Ischemic cerebrovascular disease
These lesions can be secondary to either hemorrhagic or ischemic stroke. ... Despite the large amount of information about small vessel occlusive disease, ...Day-after-day Report Directory
Chronic Small Vessel Ischemia - Neurology - MedHelp
I was just received MRI results indicating Chronic Small Vessel Ischemia after episodes of occasional vaque throbbing sensations in head. Dr. followup visit next week. ...
Ischemia - Wikipedia, the free encyclopedia
Ischemia of the small bowel is called mesenteric ischemia. ... Chronic ischemia of the brain may result in a form of dementia called vascular dementia. ...
Chronic Small Vessel Ischemic Disease - Neurology - MedHelp
My MRI of the Brain shows the following results: Chronic Small Vessel Ischemic Disease in the Periventricular White Matter, Adjacent to the Atrium and Trigones of the ...
What Is Small Vessel Ischemia?
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How do you get small vessel ischemic changes? FunAdvice.com
FunAdvice How do you get small vessel ischemic changes? has 1 answers. Ask any Health questions you have and get fast answers.